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List of Health Diseases

ACDHIOPR • #

More than 1,400 scientific studies (Pubmed.com) have been conducted on the health effects of Spirulina.  Following is a summary of some of the findings related to various common health issues and diseases.

 

A


Adiopophepatosis (Fatty Liver Disease)

  • Condition suppressed, and recovery stimulated in rats [2] 
  • 6 g Spirulina/day for 6 months reduced markers of fatty liver disease and improved quality of life in human study [10]

Allergic Rhinitis

  • Human subjects fed 2 g Spirulina/day had reduced IL-4 levels by 32% from PHA-stimulated peripheral blood mononuclear cells [26]

Arthritis

  • Spirulina protected (almost completely) against adjuvant-induced inflammation in a mouse model of arthritis [1] 
  • Protects against collagen-induced arthritis in rats [28]
  • Protects against zymosan-induced arthritis in mice [32]

Atherosclerosis

  • Vascular smooth muscle cells treated with sodium spirulan (a sulfated polysaccharide isolated from spirulina) decreased cell proliferation (a marker of atherosclerosis) in bovine cell culture [5]

C


Cancer (anti-Tumor)

  • Tumor invasion and metastasis was inhibited by calcium spirulan isolated from Spirulina in human cell culture [11] 
  • Oral leukoplakia (lesions on the mouth) caused by tobacco chewing was significantly reversed by 1 g/day Spirulina intake for 12 months [12]
  • Studies showed that beta-carotene, a nontoxic carotenoid had a cytostatic and cytotoxic dose-dependent effect on hamster and human cell lines [13]
  • An extract of Spirulina-Dunaliella shown to prevent tumor development in hamster buccal pouch [13]

D


Diabetes

  • Spirulina water-soluble fraction effective in lowering serum glucose at fasting in rats. Spirulina water-insoluble fraction suppressed glucose level at glucose loading [22]
  • Phycocyanin from Spirulina protected against oxidative stress and renal dysfunction caused as a complication of diabetes (diabetic nephropathy) using a mouse model of diabetes [4]

H


Herpes

  • An extract of Spirulina inhibited the adsorption and penetration of Herpes simplex virus type 2 into human cells in culture [8] 
  • Calcium spirulan isolated form Spirulina inhibited penetration of virus into human cells in culture [31]

HIV

  • A Spirulina extract inhibited HIV-1 replication in human T-cells, peripheral blood mononuclear cells, and Langerhans cells in culture [29] 
  • Calcium spirulan isolated from Spirulina showed potent anti-HIV activity in HIV infected human CD4-positive cells [30] 
  • Calcium spirulan isolated form Spirulina inhibited penetration of virus into human cells in culture [31] 

Hyperlipidemia(Increased Blood Lipid Levels)

  • Total cholesterol level in serum lowered. HDL(good)-chloesterol level increased, while LDL(bad)-cholesterol level suppressed in rats fed with Spirulina [9] 
  • Rate of increase of triglycerides level in serum and liver suppressed by lipase activity in rats fed with Spirulina [24] 
  • In 30 human patients fed Spirulina, total serum cholesterol, LDL- cholesterol, and athero-genic index lowered. HDL-cholesterol increased [33] 
  • 1 g spirulina daily for 3 months decreased LDL-cholesterol, and triglyceride levels in humans [10]

I


Immune System

  • 10 human subjects taking a commercial extract of Spirulina for 7 days showed increased NK cell activity and NK- and T-cell markers [15] 
  • Spirulina enhanced humoral and cell-mediated immune function in chickens [17]

 Intestinal Flora

  • Population of Lactobacillus and Bifidobacteria in the intestine of rats notably increased [21]

M

Mental Wellness

  • A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men [32] 
  • Functional characters evaluation of biscuits sublimated in pure phycocyanin isolated from Spirulina and Spirulina biomass [34]
  • Combination of Spirulina with glycyrrhizin prevents cognitive dysfunction in aged obese rats [35]

O


Obesity

  • Double-blind cross-over study vs. placebo supplemental dietary intake of 2.8g of Spirulina 3 times per day over 4 weeks showed statistically significant reduction of body weight in obese human outpatients [23] 
  • Humans fed 4.5 g/day Spirulina showed reduced systolic and diastolic blood pressure [25]

P


Postprandial lipemia (excessive fat- blood levels after a meal)

  • 41 human subjects consumed 5 g/day. TAG levels in blood were lower in blood after Spirulina treatment than before [27]

R


Radioprotective Effect

  • Extract of Spirulina resulted in significant reduction of micronucleus frequencies induced by gamma-radiation in mice [18] 
  • Rats given Spirulina for 10 days had a significantly reduced increase in oxidative stress markers in response to gamma-irradiation [19]

Renal (Kidney) Toxicity

  • Rats fed a diet including Spirulina showed protective effect against renal failure induced by inorganic mercury and 3 known pharmaceuticals: para-aminophenol, gentamicin, and cisplatin [20]

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